About Foodsmart:

Foodsmart is the leading Foodcare platform in the U.S., built to deliver nutrition-driven healthcare at scale. Powered by a national network of Registered Dietitians, Foodsmart combines personalized clinical nutrition care, behavior change tools, and food benefits to improve member health outcomes while lowering healthcare costs.

Our platform is designed to foster healthier food choices, drive lasting behavior change, and deliver sustainable health outcomes. Through our highly personalized, digital platform, we guide more than 3 million members—including those in employer-sponsored health plans, regional and national Medicaid managed care organizations, Medicare Advantage plans, and commercial insurers—on a tailored journey to eating well while saving time and money.

Foodsmart seamlessly integrates dietary assessments and nutrition counseling with online food ordering and cost-effective meal planning for the entire family, optimizing ingredients both at home and on the go. We partner with national and regional retailers across the U.S., many of whom accept SNAP/EBT, making healthier food more accessible. Additionally, we assist members with SNAP enrollment and management, providing tangible access to nutritious food. In 2024, Foodsmart secured a $200 million investment from TPG’s Rise Fund, which supports entrepreneurs dedicated to achieving the United Nations’ Sustainable Development Goals. This investment helps us expand our reach, particularly to low-income workers who are disproportionately affected by diet-related diseases.

At Foodsmart, our mission is to make nutritious food accessible and affordable for everyone, regardless of economic status. We are committed to a set of core values that shape our culture and work environment:

👥 Customer First - You start with the member and work backwards.

🚀 Make It Happen - You act with urgency, use data, and hold high standards.

🤝 One Team - You collaborate with respect and commit as a group.

Whether you’re a dietitian, a commercial leader, or a technologist, working at Foodsmart means being part of a team that is passionate, supportive, and driven by a shared purpose. Join us in transforming the way people access and enjoy healthy food.

About the Role:

Foodsmart’s value proposition rests on a claim: we improve outcomes for the members who need it most, and we save payers real money doing it. We’re looking for a Senior Director of Clinical Intelligence who can make that claim airtight: rigorous enough to hold up against a payer’s own actuarial team, and clear enough to become the evidence the rest of the company builds on.

This is the analytical center of gravity for Foodsmart’s ROI and clinical outcomes story: the research, the methodology, and the evidence base that everything else gets built on. It’s also our most senior data science leadership role, reporting directly to the VP of Analytics & Data Science. You’ll lead a small team while staying deeply hands-on with the research and methodology yourself, and you’ll be expected to use AI as a genuine force multiplier, to move faster, go deeper, and extend your reach well beyond what the team size alone would suggest.

You’ll be the voice Foodsmart puts in the room when the conversation turns to outcomes and value. This isn’t the role that carries our overall client narrative, that lives with our go-to-market and client teams, but on research and ROI specifically, you’re the credible technical authority, whether that’s in front of a payer’s actuarial team, an external research partner, or our own leadership.

We’re looking for someone who has done this exact work before, repeatedly: a health economist or actuary with deep, hands-on research experience, not someone building this skill set for the first time. The technical bar here is causal inference and ROI methodology, not data engineering.

You will:

• Own Foodsmart’s ROI and clinical outcomes methodology: identifying which member populations we help the most, and quantifying the value we deliver for both members and payers.
• Represent that methodology directly to payers and external actuarial firms, defending our approach under real technical scrutiny, not just presenting a final number.
• Build our ROI and evidence methodology as a scalable system, one that extends to new populations and new payer conversations without being rebuilt from scratch each time.
• Own our clinical research agenda: turning our results into white papers, publications, and external research output that build Foodsmart’s credibility in the market.
• Partner with our clinical team to translate research findings and best practices into how care is actually delivered, closing the loop between evidence and practice.
• Serve as the internal expert on clinical outcomes, feeding that expertise into the broader external story Foodsmart tells clients and prospects, without owning that story yourself.
• Lead and develop a small team while staying hands-on with the core research and methodology work yourself, and lean on AI and other tooling to extend how much ground you and your team can cover.

You are:

• A credentialed, seasoned expert who’s done this work repeatedly, not someone learning ROI methodology on the job.
• Comfortable being the technical counterpart to a payer’s own actuarial team: rigorous, unintimidated by scrutiny, and able to defend methodology choices in real time.
• A genuine researcher. You think in terms of evidence and publication-quality rigor, not just internal reporting.
• Able to translate deep technical findings into how care actually gets delivered, working hand in hand with clinical and care delivery teams.
• Someone who treats AI as a genuine lever on your own impact. You actively look for ways to use it to research faster, dig deeper, and produce more than your headcount would suggest, and you have a point of view on where it helps and where rigor still demands a human.
• A systems builder who thinks in terms of scale: a repeatable methodology, not a one-off analysis redone for every new client or payer.
• Comfortable leading a small team while staying personally hands-on with the hardest analytical work yourself.

You have:

• Master’s degree required in health economics, biostatistics, epidemiology, economics, or a related quantitative field; PhD strongly preferred.
• Deep experience (12+ years) as a health economist or actuary, with a track record of building and defending ROI and value-based care methodology.  4+ years of team leadership experience.
• Genuine research experience, including published white papers or peer-reviewed work, not just internal analysis.
• Deep, hands-on expertise in causal inference (e.g., matched cohort design, risk adjustment, quasi-experimental methods) as applied to healthcare cost and outcomes.
• Deep, hands-on experience with healthcare claims data, both medical and pharmacy (Rx), including the practical realities of working with it for cost and utilization analysis.
• Direct experience presenting ROI and outcomes methodology to payers, actuaries, or similarly technical external audiences, and defending it under real scrutiny.
• Experience partnering with clinical or care delivery teams to translate research findings into practice.
• Comfort working directly with data (SQL, R, or Python) to conduct your own analysis. Experience building automation to scale your work through data modeling, AI tooling and dashboarding.
• Familiarity with AI-native tooling ( Claude Code or equivalent) as a way to accelerate research and analysis, though deep automation engineering is not the focus of this role.
• Excellent written and verbal communication skills, including the ability to write for external, technical, and non-technical audiences alike.

$210,000 - $245,000 a year

Role: Senior Director, Clinical Intelligence

Location: Remote, USA

Base Salary Range: $210,000 - $245,000 + bonus + benefits

Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries at our headquarters in San Francisco, California. Individual pay is determined by work location, job-related skills, experience, and relevant education.

About our benefits and perks:

✅ Remote-First Company

✅ Unlimited PTO

✅ Flexible & remote location

✅ Healthcare Coverage (Medical, Dental, Vision)

✅ 401k & bonus

✅ Registered Dietitian Sessions

Foodsmart is an Equal Opportunity Employer. It is our firm policy to extend equal employment and advancement opportunity to all applicants and employees without regard to race, color, national origin, citizenship status, religious creed, age, sex (including pregnancy, childbirth, breastfeeding, medical conditions related to pregnancy, childbirth and/or breastfeeding), gender, gender identity and expression, sexual orientation, marital status, disability (physical or mental) and/or a medical condition, genetic information, ancestry, veteran status or service in the uniformed services, and any other characteristic protected by applicable federal, state or local law.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.

4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery

GENERAL SUMMARY

Reporting to the Chief Medical Officer, the VP Clinical Development, Ophthalmology provides strategic and operational leadership for the global development of ophthalmic genetic medicines in Drug Development.

We seek an experienced physician to play a critical role at 4DMT as we spearhead the introduction of intravitreally delivered genetic medicines for the treatment of the most common causes of irreversible blindness. The VP, Clinical Development will be a primary point person for medical oversight of clinical studies, with responsibilities including medical monitoring, review and interpretation of clinical trial data, clinical trial design, protocol development, and drafting of key clinical documents such as protocols, CSRs, briefing packages, INDs, NDAs, BLAs, MAAs, and other regulatory documents. This role will be responsible for timely execution of deliverables in close collaboration with relevant internal and external partners.

RESPONSIBILITIES:

• Serve as the primary medical monitor for multiple ophthalmology clinical trials, providing expert oversight of patient safety, data integrity, and protocol adherence throughout study execution.
• Direct and mentor a team of medical monitors, ensuring high standards of medical oversight and data review, while maintaining accountability for real-time monitoring activities and timely delivery of critical clinical trial outputs.
• Provide medical leadership for cross-functional internal workstreams including pharmacovigilance, biostatistics, clinical operations, regulatory affairs, etc.
• Provide oversight and lead teams responsible for development plans, study protocols, amendments, ICFs, IBs, INDs, annual reports, CSRs, regulatory response documents, and other regulatory submissions or documents as appropriate.
• Collaborate closely with Clinical Operations and be accountable for clinical trial conduct and timelines for associated key deliverables.
• Keep up to date with compliance, SOPs and adhere to ICH, GCP, and relevant regulatory guidelines.
• Provide medical leadership for internal audits and regulatory inspections.
• Assist in preparation of materials for Advisory Board meetings, BOD meetings, etc
• Represent 4DMT and lead interactions and collaborations with potential partners.
• Represent the Ophthalmology Therapeutic Area with key external stakeholders, including patients and patient advocacy groups, external experts, investors, and the ophthalmic and biotech business communities
• Travel domestically and internationally as required, approximately 20%. Other duties as assigned; nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

QUALIFICATIONS:

Education:

• MD Degree
• Clinical training in Ophthalmology preferred
• Retina fellowship training a plus
• Board Certification (or equivalent) preferred

Experience:

• Minimum of 8 years of biopharma industry experience in drug development.
• Phase 3 ophthalmology experience; retinal disease highly preferred.
• Experience with NDA, BLA or MAA submission(s). Drug approval(s) a plus.
• Experience with gene therapy, other areas of Drug Development and commercialization is a plus.

Skills:

• Strong interpersonal skills and high emotional coefficient
• Highly effective written and verbal communication skills
• Excellent analytical, problem-solving and strategic planning skills.
• Up to date understanding of the ophthalmic competitive landscape with a focus on retina
• Prior clinical trial experience in retina highly preferred.
• Ability to understand and translate complex data to key messages
• Ability to thrive in a fast-paced environment.
• Proven ability to prioritize effectively
• Proven ability to plan and conduct clinical trials ensuring high-quality trial execution and results within established timelines; demonstrated track record working effectively in cross-functional teams and workstreams including pharmacovigilance, biostatistics, clinical operations, and regulatory affairs.
• Experience in successfully presenting and interacting with the Ophthalmic Retina Community and regulatory authorities in US, EU and APAC
• Integrated understanding of FDA, EMA, ICH, and GCP guidelines. Prior interactions with FDA and EMA regulatory agencies is desirable.
• Track record of thinking strategically and executing to strategy
• Demonstrated success in influencing colleagues and senior leaders in various departments.
• Experience building and leading teams and driving engagement in a matrixed environment.
• Attention to detail, internal drive to generate high-quality work, and sense of passion and urgency to achieve team and program goals.
• Track record of developing talent
• Demonstrates high integrity.

Physical Requirements and Working Conditions:

• Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word.
• Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met.
• Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work).

Base salary compensation range: $350,000 - $430,000

Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

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Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.

4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery

GENERAL SUMMARY

The Executive Medical Director will report to the CMO, with a dotted-line relationship to the SVP of Research & Early-Stage Product Development, and will be responsible for the design, execution, and analysis of clinical trials in the ophthalmology therapeutic area

MAJOR DUTIES & RESPONSIBILITIES:

• Clinical Development Leadership
  • Serve as the clinical lead for Phase 1 retina clinical trials, including study design, protocol development, dose escalation strategy, and safety oversight
  • Maintain accountability for study execution, data interpretation, and clinical readouts, including early signal detection and go/no-go recommendations
  • Serve as medical monitor for assigned studies, ensuring subject safety and data integrity
  • Lead cross-functional study teams (clinical operations, clinical science, biometrics, regulatory, safety, CMC, etc.) to ensure high-quality and timely trial delivery
  • Provides clinical leadership to multidisciplinary study execution teams drawn from clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharm/tox, drug safety, commercial, and alliance partners
  • Has lead accountability on the study teams for delivery of study protocols, study conduct, and study readouts
• Biomarker & Translational Strategy
  • Lead development and implementation of biomarker strategies for GA and broader retina programs
  • Collaborate with research and translational teams to identify, validate, and integrate imaging, molecular, and functional biomarkers into early-phase trials
  • Ensure biomarkers are aligned with mechanism of action, dose selection, and clinical endpoints to support decision-making and regulatory strategy
• Regulatory & Clinical Documentation
  • Serve as the primary clinical author of development plans, protocols, IBs, INDs, CSRs, and regulatory responses
  • Lead clinical contributions to IND submissions and early regulatory interactions, including Health Authority meetings for Phase 1 programs
  • Ensure accuracy, scientific rigor, and regulatory compliance of all clinical documents
• External Scientific Leadership
• Organizes and leads scientific advisory board meetings. Interacts with external experts and stakeholders to gather input.
• Works with the research organization and the portfolio management team to identify and support new project opportunities.
• Collaborates to identify program risks, and to create and implement mitigation strategies
• Other duties as assigned

QUALIFICATIONS:

Education:

• Medical Degree (M.D.), other degrees considered with relevant experience
• Residency training in Ophthalmology with a preference for subspecialty training in retina
• Board certification/retina fellowship training are a plus

Experience:

• 10+ years of clinical ophthalmology research in the biopharmaceutical industry
• Experience with medical monitoring and oversight of Phase 1 retina clinical trials
• Experience with gene therapy clinical studies
  • Experience in other phases (Phase 2, 3) of clinical research.
  • Experience with NDA/BLA/MAA submission planning and execution
  • Experience in data analysis, data interpretation, and medical writing

Other Qualifications/Skills:

• Knowledge of ICH-GCP and FDA regulatory guidelines.
• Knowledge of international regulatory guidelines
• Effective written and verbal communication skills, including public speaking

Travel: up to 20%

Physical Requirements and Working Conditions:

• Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word.
• Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met.
• Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work).

Base salary compensation range: $350,000 - 398,000

Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities